Mary L. Guye, MD, FACS, FSSO, is a fellowship-trained, board-certified Surgical Oncologist practicing at TPMG Surgical Oncology & Breast Specialists in Hampton, VA. Dr. Guye specializes in the treatment of breast cancer and melanoma, offering a multidisciplinary approach that includes evaluation, diagnosis, and surgical intervention for a variety of conditions. 

With a medical career spanning 30 years, Dr. Guye began her practice in the United States Air Force, where she served our country as a General Surgeon and Surgical Oncologist. She received her medical degree from the Uniformed Services University of the Health Sciences (USUHS), F. Edward Hebert School of Medicine in Bethesda, Maryland. Furthering her education, she completed her General Surgery Internship at Wilford Hall United States Air Force (USAF) Medical Center at Lackland Air Force Base (AFB) in San Antonio, Texas, before finishing her General Surgery Residency at Wilford Hall USAF Medical Center and the University of Texas Health Science Center in San Antonio, Texas. 

Dr. Guye joined the U.S. Air Force in 1993, where she served until retirement in 2018 as a Colonel. Before joining TPMG and opening TPMG Surgical Oncology & Breast Specialists in 2026, Dr. Guye worked as a surgical oncologist with Sentara Surgery Specialists in Newport News and serves in numerous academic appointments, including her current role as Assistant Professor of Surgery at Eastern Virginia Medical School, former Assistant Professor of Surgery at Uniformed Services University of Health Sciences, and former Clinical Assistant Professor of Surgery at Wright State University Boonshoft School of Medicine. A member of multiple professional organizations, Dr. Guye is a fellow of the American College of Surgeons, a fellow of the Society of Surgical Oncology, and a member of the American Society of Breast Surgeons and the Association of Women Surgeons. 

With a clinical focus on breast cancer and melanoma, Dr. Guye emphasizes patient education and empowerment through her practice. She treats each patient as an individual, explains their diagnosis, and ensures patients and their families have the tools they need to make the best healthcare decisions. Dr. Guye sees adults for a variety of conditions, including breast cancer, benign breast conditions, high-risk breast conditions, and melanomas, among others. 

Dr. Guye is a recipient of the Bronze Star Medal, along with numerous other awards and medals from her military career. She has served overseas in 5 combat deployments and 3 humanitarian missions. She has also been recognized by Coastal Virginia Magazine and Virginia Top Docs as a Top Doctor for multiple consecutive years. 

As a native of Hampton Roads, Dr. Guye prioritizes serving and empowering the community that raised her. When she isn’t seeing patients, Dr. Guye can be found reading, visiting the beach, spending time with family, and volunteering at her local food pantry. 

Dr. Guye warmly welcomes patients to schedule an appointment with her at TPMG Surgical Oncology & Breast Specialists.

Education

Graduate: Uniformed Services University of the Health Sciences (USUHS), F. Edward Hebert School of Medicine
Internship: General Surgery Internship, Wilford Hall United States Air Force (USAF) Medical Center, Lackland Air Force Base (AFB)
Residency: General Surgery Residency at Wilford Hall USAF Medical Center and the University of Texas Health Science Center

Interests & Activities

Fellow, American College of Surgeons, and Society of Surgical Oncology
Member, American Society of Breast Surgeons and the Association of Women Surgeons